Glandular and extraglandular expression of costimulatory molecules in patients with Sjogren's syndrome
نویسندگان
چکیده
منابع مشابه
Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome.
OBJECTIVES To investigate the expression and regulation of CD80, CD86, and CD28 costimulatory molecules in sialoadenitis and interstitial nephritis in patients with Sjögren's syndrome (SS). METHODS Expression of CD80, CD86, and CD28 molecules was studied by immunohistochemical staining of lip biopsy specimens obtained from patients who had sialoadenitis associated with SS, and renal biopsy sp...
متن کاملSjogrens syndrome--the non-apoptotic model of glandular hypofunction.
The ‘classical’ model to explain glandular hypofunction in Sjögrens syndrome (SS) is tissue loss secondary to immune attack mediated by a combination of apoptosis and cytotoxic cell death (reviewed recently by Ramos-Casals and Font [1]). In this model, the process of glandular destruction is made self-sustaining by the continued production of novel ‘self ’ antigens, secondary to apoptotic bleb ...
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چکیده ندارد.
Profiling Micro-RNA expression in patients with Primary Sjogrens Syndrome – contribution to disease pathogenesis
Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanism...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2001
ISSN: 0003-4967
DOI: 10.1136/ard.60.5.473